In addition, knockdown of hexokinase-1 (HK-1) in U937 and OCI-AML3 cells, as well as treatment of the above mentioned AML cell lines and primary AML blasts with the glycolysis inhibitor 2-deoxy-D-glucose (2-DG) increased the sensitivity to the chemotherapeutic agent Ara-C [30]. This evidence concerns the gene HK1 and acute myeloid leukemia.