The markers such as collagen I, α-SMA, PAI-1, E-cadherin and N-cadherin in animals of PHMG-induced model were examined whether there were any changes of fibrosis and EMT-related markers by CG-745 administration since PHMG instillation provoked a progression to lung fibrosis in mice. This evidence concerns the gene SERPINE1 and pulmonary fibrosis.