Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is an active compound found in chili pepper that has been shown to inhibit migration and angiogenesis of B16-F10 melanoma cells in vitro; the mechanism of action was via the inhibition of the PI3K/Akt/Rac1 signal pathway [126]. This evidence concerns the gene PIK3CA and melanoma.