A recent report suggested the involvement of activated Akt/mTOR and its downstream effector molecules p-4E-BP1 (S65) and p-S6K in MCC cells [109], and a positive correlation between MCV specific T cell antigen and the translation initiation factor 4E-BP1 was testified to activate Akt/mTOR signaling in MCV positive tumor [184]. This evidence concerns the gene EIF4EBP1 and Merkel cell skin cancer.