Wang et al. reported that SKLB-M8 treatment inhibited the proliferation and the expression of cdc2, induced G2/M arrest, and elicited apoptosis via the down-regulation of activated Akt/mTOR signaling pathway in melanoma models as well as inhibited angiogenesis associated with inhibition of ERK1/2 phosphorylation (Table 1) [87,88]. This evidence concerns the gene MAPK3 and melanoma.