The 17q11.2 microdeletion fully encompassing NF1 is known to be linked to a more severe phenotype with dysmorphic facial features, overgrowth or tall-for-age stature, significant delay in cognitive development, large hands and feet, hyper flexibility of joints, muscular hypotonia, and malignancies, such as the development of malignant peripheral nerve sheath tumor (MPNST) [17,18]. Here, NF1 is linked to malignant peripheral nerve sheath tumor.