Furthermore, a recent study demonstrated that chemerin suppresses hepatocellular carcinoma (HCC) metastasis through upregulation of expression and phosphatase activity of tumor suppressor PTEN by interfering with PTEN-CMKLR1 interaction, resulting in decreased p-Akt levels, also leading to suppressed migration, invasion and metastasis of HCC cells in vitro. This evidence concerns the gene RARRES2 and hepatocellular carcinoma.