Using the GEPIA server analyzing RNAseq data of 9736 tumors and 8587 normal samples of the TCGA and GTEx projects revealed chemerin mRNA expression to be down-regulated in 23 of 31 cancer entities (74.2%), but to be up-regulated in eight of 31 cancer types tested (25.8%; Supplemental Figure S2) [32]. This evidence concerns the gene RARRES2 and cancer.