In contrast, phosphorylation of p38 and ERK1/2 MAP kinases was reported to be elevated in gastric cancer cells after treatment with chemerin in vitro, leading to increased invasiveness of these cells and up-regulation of vascular endothelial growth factor (VEGF) and matrix metalloproteinase 7 (MMP-7) [54]. The gene discussed is MMP7; the disease is gastric cancer.