FOS and hepatocellular carcinoma: While c-FOS has been initially demonstrated to act as an oncogene, which is associated with tumor progression and decreased survival of cancer patients [45], recent studies also discovered a tumor-suppressing and pro-apoptotic function of c-FOS in various cancer types including ovarian cancer, hepatocellular carcinoma or prostate cancer and has been shown to be associated with increased survival in ovarian cancer [46,47,48,49,50].