In addition, nintedanib potentially regulates the Src homology region 2 domain-containing phosphatase-1 (SHP-1) autoinhibition causing an increase in signal transducer and activator of transcription 3 (STAT3) dephosphorylation through a kinase-independent mechanism, in xenograft HCC tumor mouse models [80]. This evidence concerns the gene STAT3 and neoplasm.