Neuroinflammation in aSAH has been proposed to elicit brain injury, vasospasm, and subsequent brain ischemia and injury [21,22], it is plausible that improvements of cortical microcirculation, tissue oxygenation, as well as cognitive/motor functions are secondary to the global alleviation of neuroinflammation by IGF-1 in the aSAH-injured brain. The gene discussed is IGF1; the disease is brain ischemia.