In particular, in a mouse model of zymosan-induced sensitization of colonic mechanoreceptors, both ASIC3 and TRPV1 participated in development of chronic hypersensitivity to colorectal distension in the absence of inflammation, suggesting that both ASIC3 and TRPV1 may contribute to non-inflammatory visceral hypersensitivity, typical of IBS [249]. The gene discussed is TRPV1; the disease is irritable bowel syndrome.