In particular, in a mouse model of zymosan-induced sensitization of colonic mechanoreceptors, both ASIC3 and TRPV1 participated in development of chronic hypersensitivity to colorectal distension in the absence of inflammation, suggesting that both ASIC3 and TRPV1 may contribute to non-inflammatory visceral hypersensitivity, typical of IBS [249]. This evidence concerns the gene ASIC3 and irritable bowel syndrome.