Induction of TNBS colitis resulted in a significantly (p < 0.001 and p < 0.01 respectively) increased splenic gene expression of the both transcription factors, RORγ and Foxp3 (4 ± 0.5 vs 1.1 ± 0.4 and 4.8 ± 0.1 vs 1.7 ± 0.4, respectively, by comparison to controls) (Figure 4c,d). The gene discussed is FOXP3; the disease is colitis.