TRPV4 and diabetes mellitus: Taking these results together in conjunction with a recent study that showed the co-localization of TRPV4 channels with caveolin-1 in the caveolae of arterial endothelial cells [78], it is apparent that a decrease in the number of caveolae might underpin the reduced expression of endothelial TRPV4 channels and thus impaired EDH during diabetes in some vascular beds.