As with type 1 diabetes, reduced EDH-mediated responses in these rodent models of type 2 diabetes have been reported in a number of vascular beds including mesenteric [35,36,37,38,39,40,41,42], coronary [43], renal [44], cerebral [45], and penile [46] arteries as well as in epineurial arterioles of the sciatic nerve [47]. This evidence concerns the gene GJB6 and type 2 diabetes mellitus.