NFE2L2 and diabetes mellitus: Interestingly, in coronary arteries from diabetic mice, an induction of nuclear factor erythroid-2-related factor-2 (Nrf2), a master regulator of antioxidants, restored the BKCa channel β1 subunit expression and thus augmented BKCa-mediated vasodilation [165,166], indicating that Nrf2 could be a potential therapeutic target to ameliorate impaired EDH in diabetes in some vascular beds.