Since the degradation of endothelial glycocalyx seems to contribute to the impaired EDH-mediated responses in diabetes through a reduction in the SKCa channel input to EDH [88], it is tempting to speculate that SGLT2 inhibitors ameliorate impaired EDH in diabetes by restoring the integrity of the endothelial glycocalyx. The gene discussed is SLC5A2; the disease is diabetes mellitus.