Since the plasma concentration of ox-LDL is elevated in STZ-induced diabetic rats [70], and because LPC inhibits EDH-mediated responses in some vascular beds [67,71,72], it is tempting to speculate that LPC released from ox-LDL, at least in part, impairs EDH-mediated responses by decreasing endothelial Ca2+ rise in STZ-induced diabetes. Here, GJB6 is linked to diabetes mellitus.