Even if HIF-1α-dependent molecular mechanisms in chemo-sensitivity have been only partially elucidated, suppression of p53 and activation of nuclear factor κB (NF-κB) seem to play a key role in hypoxia-related 5-fluorouracil (5-FU) and cisplatin (CDDP) sensitivity in human GC cells [49]. The gene discussed is NFKB1; the disease is gastric cancer.