UCHL1 and carcinoma: Since there is evidence that high levels of UCH-L1 expression correlate with the more progressive, metastatic stages of malignancies, the inhibitory effects of LDN-POx on UCH-L1 DUB activity would be beneficial specifically for poorly differentiated and highly invasive carcinomas such as oral squamous cell carcinoma (OSCC) and EBV-positive NPC.