TF and infection: The process of metal piracy is implicated as a critical virulence factor for N. gonorrhoeae, as a human male infection model demonstrated that mutant gonococci incapable of utilizing iron from transferrin and lactoferrin were incapable of infection [19], and TdfH production allows the pathogen to survive in Neutrophil Extracellular Traps (NETs), which are highly enriched for Calprotectin, in vitro [18].