Late HIV diagnosis, defined as the presence of a baseline CD4 cell count ≤ 350 cells/mm3 or the presence of an AIDS-defining condition at diagnosis, was higher in routine clinical practice despite being non-statistically significant (54.5% vs. 71.4%, p = 0.665); this included advanced HIV disease (≤ 200 cells/mm3), with 40.9% in the DRIVE program vs. 57.1% in routine clinical practice (p = 0.667). This evidence concerns the gene CD4 and AIDS.