To explore the hubgenes in the network, indicating a critical role in the process of BC carcinogenesis, the degree and betweenness centrality were evaluated, and the following top 10 hub_genes were extracted using the cytoHubba app: CDK1, CENPM, CENPF, KNTC1, DSN1, HIST1H2BJ, RAD51, EZH2, EXO1, and BRCA1 (Fig 4B). This evidence concerns the gene EZH2 and breast cancer.