VEGFA and neoplasm: Moreover, there exists a considerable number of data reporting on the capability of Q to induce cell cycle arrest and apoptosis and to being an inhibitor of carcinogenesis and angiogenesis.20, 21 Several studies have highlighted that the anti‐cancerous property of Q is due to the down‐regulation of the VEGF and Hypoxia‐inducible factor‐1 (HIF‐1) expression.22 It has been shown that Q has negative23 as well as positive effects24 on HIF‐1 and VEGF expressions in different types of cell and, to date, several uncertainties have been raised regarding its absorption and availability in tumour.