EGF activates Pyk2, regulates functions of downstream Twist‐1,2, CD44, Snail‐1,2, matrix metalloproteinase‐10 (MMP‐10), β‐catenin, fibronectin, vimentin, E‐cadherin, ZO‐1, and Zeb‐1,2, promotes EMT, migration, invasion, and metastasis of breast cancer cells. Here, PTK2B is linked to breast carcinoma.