PTK2B and cancer: In numerous researches in vivo and in vitro, overexpression of Pyk2 is found in different malignant tumors (Sun et al., 2007; Zhang et al., 2008; Hsiao et al., 2016) and it is implicated in multiple signal transduction cascades, which regulate cancer cell proliferation, apoptosis, and invasion (Okigaki et al., 2003; Sun et al., 2008; Wiese et al., 2015).