Pyk2 promotes EMT by downregulating epithelial gene cytokeratin and E‐cadherin and upregulating mesenchymal gene Twist, N‐cadherin, fibronectin, hydrogen peroxide inducible clone‐5 (Hic‐5) and STAT5b, thus contributing to HCC cell motility and migration (Sun et al., 2011). This evidence concerns the gene PTK2B and hepatocellular carcinoma.