The FERM domain of Pyk2 could mediate both protein‐protein and protein‐membrane targeting interactions and plays a critical role in Pyk2‐induced migration of tumor cells (Hirao et al., 1996; Hamada et al., 2000, 2003; Pearson et al., 2000; Loftus et al., 2009). Here, PTK2B is linked to neoplasm.