As NPPA has been demonstrated to inhibit NFAT activation,25 this DS‐induced up‐regulation of NPPA could explain why RCAN1 was not up‐regulated in DS‐treated rats, even though crucial Ca2+‐handling genes (ATP1A2, SERCA2A and PLN) were dysregulated upon DS‐induced hypertension. This evidence concerns the gene NPPA and hypertensive disorder.