As peroxisomes lack a respiratory chain, electrons from FADH2 are transferred directly to O2, generating H2O2 and heat.45 In line with previous studies,46 obesity appeared to induce peroxisomal FAO, as illustrated by higher expression of peroxisomal‐specific Acyl‐Coenzyme A Oxidase 1 (ACOX1) and Acyl‐CoA Dehydrogenase Very Long Chain (ACADVL). The gene discussed is ACADVL; the disease is obesity due to melanocortin 4 receptor deficiency.