The murine model of targeted podocin gene inactivation was shown to develop the entire characteristics of FSGS with NS until the fourth week after induction3 allowing us to carefully examine renal function in a time‐dependent manner over a longer time period then in animal models of PAN‐induced nephrosis or doxorubicin‐induced NS.10, 14, 16, 17 We have observed sodium retention, hypertension and gross/unselective proteinuria to occur in a chronologic successive order. This evidence concerns the gene NPHS2 and Hypertension.