For example, EZH2 overexpression, induced by transcriptional regulator NF‐YA, could enhance STAT3 activity by mediating its lysine methylation to up‐regulate VEGF expression and promote angiogenesis in melanoma cells.33 Moreover, EZH2 could also promote phosphorylation of pY705 on STAT3 via other mechanisms independent of STAT3 methylation. This evidence concerns the gene VEGFA and melanoma.