Accumulating evidence suggests that tumour glycolysis, known as ‘Warburg effect’ and used by most cancer cells to generate energy for rapid growth and cancer metastasis, exerts great influences on EMT and invasion of various cancers.10, 34, 35 Here, we revealed that silencing of EZH2 inhibited the tumour glycolysis, EMT, migration and invasion of OSCC cells. The gene discussed is EZH2; the disease is neoplasm.