Venkatesan and colleagues demonstrated that EZH2 interaction with VAV family proteins, which were involved in migration and proliferation of cancer cells, contributed to initial neoplastic transformation via activating STAT3 pathway.32 In this study, through Western blot analysis, we found that up‐regulation of EZH2 could significantly enhance the expression of tyrosine‐phosphorylated STAT3 at the 705 residue, while total STAT3 expression remained unchanged. Here, EZH2 is linked to cancer.