However, Ozes et al reported that phosphorylation of EZH2 at threonine 372 could inhibit ovarian carcinoma cells proliferation and migration in vitro and decrease ovarian xenograft tumour growth in vivo, through binding to STAT3 and reducing levels of pSTAT3, which might be due to the differences in cancer microenvironment.41 This evidence concerns the gene STAT3 and ovarian carcinoma.