Given that hinokitiol alleviates the anemia of the Belgrade rat (Grillo et al. 2017) and that the anemia derives from a G185R mutation in DMT1 (Fleming et al. 1998), this result is not surprising but its novelty depends on the gradient here coming from experimental intervention rather than the mutational loss of the gene product. The gene discussed is SLC11A2; the disease is anemia (phenotype).