In their recent GWAS, the IAMDGC identified a susceptibility locus for AMD on chromosome 8p21.3 with the most significant signals coming from rs13278062 and rs79037040 in the TNFRSF10A/LOC389641 and TNFRSF10A genes (Fritsche 2013, 2016). Here, TNFRSF10A is linked to age-related macular degeneration.