The proteins encoded by SERPINB5 (maspin) and SERPINB13 (headpin) are known for their anti-angiogenic properties, which may have implications for the choroidal neovascularization subtype of advanced AMD (Pescosolido et al. 2014; Shellenberger et al. 2005; Zhang et al. 2000). This evidence concerns the gene SERPINB5 and age-related macular degeneration.