Polymorphisms and deletions in CFH and CFHRs have been previously associated with AMD (Edwards et al. 2005; Fritsche et al. 2016; Hageman et al. 2005; Haines et al. 2005; Klein et al. 2005; Lores-Motta et al. 2018; Martinez-Barricarte et al. 2012), including rare variants in CFH (Hoffman et al. 2014; Raychaudhuri et al. 2011) and a protective deletion of CFHR1 and CFHR3 (Fritsche et al. 2010; Hageman et al. 2006; Hughes et al. 2006). This evidence concerns the gene CFH and age-related macular degeneration.