Association signals were not detected in the 5 directly genotyped variants in the LCN9 gene on chromosome 9 or the 27 directly genotyped variants in the RTEL1/RTEL1-TNFRSF6B locus on chromosome 20 from the IAMDGC GWAS for advanced AMD. This evidence concerns the gene TNFRSF6B and age-related macular degeneration.