Another gene from our 1-HLOD support interval, TCF4, has repeatedly been association with Fuchs endothelial dystrophy, which is characterized by the deterioration of the corneal epithelium (Baratz et al. 2010; Kuot et al. 2012; Li et al. 2011; Riazuddin et al. 2011; Thalamuthu et al. 2011). The gene discussed is TCF4; the disease is Fuchs' endothelial dystrophy.