Immune checkpoint inhibitors (ICI) targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell dealth-1/program cell death ligand-1 (PD-1/PDL-1) proteins are able to augment host anti-tumor immune response (Kantarjian et al. 2016; Patel and Minn 2018). This evidence concerns the gene CTLA4 and neoplasm.