Chronic inflammation, as indicated by the continuous presence of serum inflammatory mediators such as C-reactive protein (CRP), fibrinogen, and various interleukins, is a risk factor for numerous age-related, chronic disorders such as diabetes, cardiovascular disease (CVD), cancer, and the metabolic syndrome (1, 2), as well as increased frailty and cognitive decline (3). The gene discussed is CRP; the disease is Mental deterioration.