CASP1 and rheumatoid arthritis: For example, patients with Sjogren’s syndrome (Niu et al., 2015; Vakrakou et al., 2018), rheumatoid arthritis (Choulaki et al., 2015; Guo et al., 2018; Yang et al., 2016), and systemic lupus erythematouses (Zhang et al., 2016), dermatomyositis and polymyositis (Yin et al., 2016) have the feature of caspase 1-mediated release of inflammatory factors.