INS and hyperinsulinism: Weight loss is an effective strategy in treating anovulation and menstrual irregularity in females with PCOS and many researchers conclude that these improvements are related to reductions in elevated blood insulin levels (hyperinsulinemia) and improvements in insulin sensitivity [1, 34, 35, 42]; insulin resistance is considered, by many, a casual pathway in the development of PCOS [28, 43, 44].