MMP2 and central nervous system cancer: Similarly, silencing of the MMP-2 gene, using MMP-2 siRNA transfection inhibited radiation-enhanced viability of glioma cells [34] and also suppressed the growth of esophageal carcinoma cells [35].However, pMMP-2 pro-death and pro-life activity may be due to ROS generation that promotes anti- or pro-tumor effects with different mechanisms and genomic instability [31].