The F2R-like trypsin receptor 1 (F2RL1) (also known as PAR2), a protease-activated receptor expressed on the cell surface of various tissue types, has been shown to play a regulatory role in PI3K signaling and contribute to a broad range of normal and disease-related processes, including embryogenesis, inflammation, and cancer 30-32. Here, F2RL1 is linked to cancer.