Moreover, rescue experiments showed that the decreased IC50 for cytotoxic agents observed in CDYL-deficient H69AR cells was rescued by siRNA-mediated knockdown of CDKN1C (Figure 4F-G), indicating that CDYL mediated the chemoresistance of SCLC cells through its downstream mediator CDKN1C. The gene discussed is CDKN1C; the disease is small cell lung carcinoma.