SLC5A2 and renal fibrosis: Nevertheless, the report showing suppressed renal fibrosis in Pin1 KO mice fed a high-phosphate diet suggests that increased Pin1 in diabetic mice might also be involved in diabetic kidney impairment, making at least a limited contribution, and also that normalization of the Pin1 expression level by the treatment with an SGLT2 inhibitor is involved in its protective effect.