Given the inconsistent confounding effects of cell-type, we considered cg16658191 within the hexokinase-1 (HK1) gene as the finding with the most consistent evidence for an association with asthma and carried this CpG forward for cross-sectional analyses with allergy, inflammation and lung-function, as well as prospective analyses with infant respiratory outcomes. The gene discussed is HK1; the disease is asthma.