The larger size of CD45highLy6C+Ly6G−F4/80+CD11b+CD11c− macrophages and CD45highCD11b+F4/80−Ly6Ghi Ly6Cmed neutrophil infiltrates induced by virulent strains (McKrae, 17, KOS79) correlated with the severity of corneal disease. This evidence concerns the gene ITGAX and corneal disorder.