NLRP3 and infection: Infection of human corneal epithelial cells with virulent HSV-1 laboratory strains (McKrae or 17) (Figures 5A,B) or with the clinical isolate KOS79 (Figures 5C,D) induced a significant early expression of NLRP3 and IFI16 inflammasomes, compared to a steady level of control β-actin (P < 0.05).