Since induction of inflammasomes triggers Caspase-1 activation, we next determined whether corneal infection with virulent HSV-1 strains would enhance the expression levels of one or several of the five major inflammasomes: NLRP3, NLRP6, NLRP12, IFI16/p204, and AIM2. The gene discussed is NLRP12; the disease is corneal infection.