Importantly, a recent study of Wang et al. [29] investigated the underlying role of IL-35 recombinant protein in colitis, and uncovered that IL-35 recombinant protein reverses inflammatory reaction by increasing the secretion of IL-10 and downregulating the expression of pro-inflammatory cytokines IL-6, TNF-α and IL-17 in acute colitis model. The gene discussed is IL17A; the disease is colitis.