Continuous hyperglycemia as the key initiating factor, could eventually provoke heightened excitability of peripheral nerve sensory and spinal dorsal horn neurons by controlling neuronal voltage-gated ion channels and affecting the production of nerve growth factor (NGF), leading to the spontaneous discharge of neurons and increased central sensitization, which is the basis of neuropathic pain [15, 16]. The gene discussed is NGF; the disease is Hyperglycemia.