They promote tumor growth, angiogenesis and the malignant progression of various solid tumor through direct cell–cell contact or by paracrine secretion [8, 9], up-regulation of epidermal growth factor (EGF), interleukin-6 (IL-6), insulin-like growth factor, or hepatocyte growth factor in CAFs has been reported recent years [10–12]. The gene discussed is EGF; the disease is neoplasm.