To test this hypothesis, we treated 4 human pancreatic cancer cell lines (MiaPaCa-2, BxPC-3, SW1990, and Panc-1) with VEDT alone, TRAIL alone, or both drugs combined and then accessed cell survival, caspase-3 enzyme activity, and apoptosis. This evidence concerns the gene TNFSF10 and familial pancreatic carcinoma.