CCL2 and neoplasm: In the coculture media of CCL2-expressing tumor cells with macrophages, the number of tubes that formed was significantly higher than that in the culture media from CCL2-expressing tumor cells only [U87 MG; CCL2 vs. CCL2 with macrophages (p = 0.0040), LN 18; CCL2 vs. CCL2 with macrophages (p = 0.0017)] (Fig. 3B,C).