We further found these CpGs to be enriched for involvement in the RA pathway (p-value = 9.47e−07); particularly, 4 of these CpGs reside in HLA genes (or in an intergenic HLA region) that were previously reported in GWAS as RA genetic risk loci: HLA-DRA, DRB5, DQA1, and DQA2 (Supplementary Data 2). The gene discussed is HLA-DRB5; the disease is rheumatoid arthritis.