Other ruthenium complexes also exhibited in vivo antitumor activity in xenotransplantation models, such as the ruthenium(II) complex with xanthoxylin in HepG2 cells12, a ruthenium(II) complex with a phenylterpyridine derivative in human melanoma A375 cells31, a ruthenium (II) imidazole complex in A549 cells32 and a ruthenium(II) triazine complex against CD133 + HCT-116 (cancer stem cells derived tumor) xenografts33. This evidence concerns the gene PROM1 and melanoma.