Here, we aimed to characterize the vascular effects of PCSK9 inhibition in APOE*3Leiden.cholesteryl ester transfer protein (CETP) mice, a mouse model for familial dysbetalipoproteinemia with human-like lipoprotein metabolism30–32, on atherosclerosis development, inflammation and EPC and CAC number. Here, CETP is linked to hyperlipoproteinemia type 3.