Although clinical tests were unsuccessful in detecting changes of disease status at post-BMT compared to pre-BMT (Supplementary Table 4B), single-cell DNA-seq uncovered expansion of the oncogenic clone of cells carrying both TP53 and SF3B1 mutations from 0% before BMT to ~0.2% after BMT and then expansion to ~6% at AML relapse (Fig. 1D and Supplementary Table 4B), implying that exclusive and remarkable expansion of this oncogenic clone of cells might be the cause of AML relapse in this patient. Here, TP53 is linked to acute myeloid leukemia.