Combined DEGs and bioinformatics analysis indicated that the cytokine imbalance relevant to key molecules: extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase, tumor necrosis factor, colony-stimulating factor 3, IL-6 and interferon gene (IFNG) were responsible for the common comprehensive mechanism of RA [35]. The gene discussed is MAPK3; the disease is rheumatoid arthritis.