PRTN3 and rheumatoid arthritis: In EWAS comparisons of ACPA-positive and ACPA-negative subjects (excluding the 8 self-reported RA patients), we identified 2047 DMCs (q value ≤ 0.01); 668 were hypomethylated and 1379 hypermethylated (model I, see Table 2 for a summary of all models fit and the number of DMCs and DMRs identified).