Furthermore, apoptosis was higher in IL-30−/−tumors, when compared with control tumors from both IL-30KO and WT mice (p < 0.01), but also when compared with IL-30-silenced tumors from WT mice (p < 0.01) (Table 1 and Fig. 1H), thus, suggesting the involvement of host-derived IL-30 in regulating cancer cell apoptosis, whereas proliferation and stemness remained unaltered. Here, IL27 is linked to cancer.