Killing of PC-SLCs by MHC class I-restricted CD3+CD8+T cells, involving TRAIL-mediated apoptosis or perforin-mediated lysis of tumor cells [45], may not be ruled out, although CD4+ T cells were consistently more represented than CD8+ cells and were the prevalent immune cell population in tumors grown in IL-30KO mice. Here, PRF1 is linked to neoplasm.