We previously observed that IL-30 expression typically involved high grade and stage of disease [6], therefore, we analyzed (n.112) PC samples, classified as Gleason score 8 to 10 (high-grade tumors), from patients with stage III disease (high-risk, clinically localized PC), a class of patients whose therapeutic management is still debated and needs to be improved [16]. Here, IL27 is linked to pachyonychia congenita.