In the tumor microenvironment (TME), IL-30 expression was evident in cancer cells forming shPIN-SC tumors (in both WT and KO mice), but also in CD11b+Gr-1+ myeloid-derived cells (MDCs) and macrophages which infiltrated shPIN-SC tumors and, to a lesser extent, IL-30shPIN-SC tumors growing in WT mice, whereas, it was lacking in IL-30-silenced tumors developed IL-30KO mice (Fig. 2A and B). Here, IL27 is linked to cancer.