Originally identified as the p28 subunit of the heterodimeric cytokine Interleukin(IL)-27 [3, 4], and found to suppress the antitumor effects of IL-27 in colon cancer [5], IL-30 is emerging as a new and intriguing factor that may condition PC onset and progression [6–8]. The gene discussed is IL27; the disease is malignant colon neoplasm.