HDAC9 and metabolic disease: In this sense, we hypothesized that the blockade of HDAC activity may lead to the maintenance of a given dynamic chromatin state that confer more plasticity to the macrophages that will be differentiated from BMMP, opening an interesting avenue of research on the potential of iHDACs as a candidate to reverse the deleterious effects of a persistent inflammation such as found in metabolic disorder and skin injuries.