Two additional studies in HGSC found that delivery of small interfering RNA against TWIST1, a transcription factor implicated in chemoresistance and EMT, sensitized ovarian tumors to platinum drugs in an in vivo model [101], and anti-tumor efficacy was further improved if nanoparticle carriers were coated in hyaluronic acid and therefore targeted to CD44+ cells [102]. This evidence concerns the gene CD44 and neoplasm.