PGK1 and urinary bladder cancer: For example, in bladder cancer, KDM3A overexpression is associated with the metabolic shift to glycolysis because the enzyme catalyzes H3K9me2 demethylation of glycolytic genes’ promoters, including SLC2A1, HKII, PGK1 (phosphoglycerate kinase 1), LDHA, and SL16A4 (monocarboxylate transporter 4), leading to their transcriptional activation [125].