Data from human HCT116 colorectal carcinoma cells revealed that Chk2-mediated phosphorylation of HuR at serine 88 and 100 and at threonine 118 facilitates the dissociation of HuR from mRNAs coding for proteins with a key role in cell proliferation and apoptosis including the tight junction protein 1, p53 binding protein mouse double minute 2 (Mdm2), K-RAS, SOX4, SIRT 1, and the Bcl-2-associated X protein (BAX) [112]. Here, ELAVL1 is linked to colorectal carcinoma.