The strong impact of caspase-2 on cell survival of colon carcinoma cells, which is underscored by the finding that the HuR-silencing-dependent sensitizing effects are almost completely rescued after genetic or pharmacological depletion of caspase-2, is unexpected since HuR can promote cell survival through targeting a broad panel of apoptosis-regulatory factors. The gene discussed is CASP2; the disease is colon carcinoma.