DAVID 6.8-based (https://david.ncifcrf.gov) [111] functional analysis revealed that HLA-DRB5, PTGS2, and UBC are associated with Parkinson’s disease and that PTGS2 and SIRT1 are involved in Alzheimer’s disease. This evidence concerns the gene HLA-DRB5 and early-onset autosomal dominant Alzheimer disease.