SPINK1-oveexpressing prostate cancer displays reduced miR-338-5p and miR-421 expression; enforced expression of miR-338-5p and miR-421 in SPINK1-overexpressing prostate cancers induces increased EZH2 expression; functional studies support a role for EZH2 as a mediator of epigenetic silencing of miR-338-5p and miR-421 ]349]. This evidence concerns the gene EZH2 and prostate cancer.