Thus, Wang and coworkers have recently reported the identification of ZBTB7A, a transcription factor of the Pokemon family, as a tumor suppressor of prostate cancer, whose inactivation (occurring in a subset of advanced human prostate cancers) leads to a marked acceleration of PTEN loss-driven prostate tumorigenesis [302,628]. The gene discussed is ZBTB7A; the disease is prostate carcinoma.