The role of autonomous androgen receptor signaling may be different following the different oncogenic mechanisms promoting prostate cancer development: thus, PIN developed by constitutive cell-autonomous AKT progressed independent of epithelial AR signaling; in contrast, PIN induced by paracrine FGF10 secretion was dependent on epithelial AR signaling [432]. Here, AKT1 is linked to prostate intraepithelial neoplasia.