circRNAs expressed in prostate cancers resulted to be tissue-specific, less tissue-specific, and ubiquitous; among circRNA transcritps that were deregulated in cancer, the majority were downregulated in cancer (with the downregulation of some circRNAsthat cannot be explained by the downregulation of the parental genes) and small subsets of circRNAs more expressaed in tumor sets that in normal counterpart (such as circular isoforms of AKT3, SDK1, LUZP2, ABCC4, and AMACR) [426]. This evidence concerns the gene AMACR and Familial prostate cancer.