In an initial study, Wang et al. showed that the glutamine transporter ASCT2, also known as SLCA5, is highly expressed in prostate cancer samples; chemical inhibition of this receptor inhibited cell cycle progression of prostate cancer cells through E2F transcription factors and reducedbasal oxygen consumption and fatty acid synthesis, thus providing evidence that downstream metabolic function is reliant on ASCT2-mediated glutamine uptake [465]. Here, SLC1A5 is linked to Familial prostate cancer.