Recently, Tomlins and coworkers have performed a study of gene expression profiling of 1577 prostate cancers representing integration between gene expression and gene alterations and showing that they can be classified into four molecular groups: 45% as ERG+, 9% as ETS+, 8% as SPINK1+, and 38% as triple-negative [366]. This evidence concerns the gene SPINK1 and Familial prostate cancer.