Thus, Park and coworkers have used prostate organoids to demonstrate that c-Myc/AKT1-transduced luminal organoids exhibit histological features of well-differentiated acinar adenocarcinoma, with AR and PSA expression, while c-Myc/AKT1-trasduced basal organoids are biologically more aggressive, with a loss of acinar morphology, low/absent AR and PSA expression [702]. The gene discussed is AKT1; the disease is acinar cell carcinoma.