NKX3-1 and Familial prostate cancer: Zhao and coworkers have used this classifier system analyzed 3782 localized prostate cancer samples and found that these tumors clustered among three different groups: Luminal A, Luminal B, and Basal: the basal tumors displayed the typical CD49f signature, while the luminal tumors were enriched in luminal markers, including KRT1B, NKX3.1, and AR [212,352].