SPOP and Familial prostate cancer: In their analysis, these authors have identified 12 genes that were recurrently mutated in primary prostate cancer: TP53, PTEN, PIK3CA, SPOP, FOXA1, MED12, CDKN1B, ZNF595, THSD7B, NIPA2, C14orf49, and SCN11A [55].