A subsequent study of the same authors was devoted to analyze the occurrence of genomic alterations in the three prostate cancer subtypes: 6q15 and 5q25 deletion was associated with subtype-1 gene expression pattern; subtype-2 was characterized by deletions at 8p21 (NKX3-1) and 21q22 (resulting in TMPRSS2-ERG fusion); and subtype-3 displayed frequent DNA copy number alterations and, particularly gains at 8q24 (MYC) and 16q13, and losses at 10q23 (PTEN) and 16q23 [343]. This evidence concerns the gene PTEN and Familial prostate cancer.