In fact, in prostate cancer cells, IKKα phosphorylates the transcription factor E2F1 on a site that promotes its nuclear translocation and the subsequent association with CBP and recruitment at the level of some important gene promoters, including Bmi1, a transcription factor playing a key role as regulator of prostate cancer self-renewal [588]. This evidence concerns the gene E2F1 and Familial prostate cancer.