PTEN and Familial prostate cancer: In line with this observation, prostate cancer specimens containing the TMPRSS2-ERG rearrangement are significantly enriched for loss of the tumor suppressor PTEN. In line with this finding, transgenic overexpression of ERG into mouse prostate tissue promoted marked acceleration and progression of high-grade prostatic intraepithelial neoplasia to prostatic adenocarcinoma in PTEN heterozygous background [109].