Using a multicolor fluorescence in situ hybridization approach, the copy number alterations of six genes known to be involved in aggressive prostate cancer (PTEN, MYC, MEN1, PDGFB, CTTNBP2, and TBL1XR1) was explored in a group of recurrent and in a group of nonrecurrent prostate cancer patients [362]. The gene discussed is PTEN; the disease is prostate carcinoma.