MYC overexpression in prostate cancer is responsible for the increase of nucleolar number and size and of a nucleolar program of gene expression in prostate epithelial cells: these effects are in part mediated through the overexpression of fibrillarin, a MYC target gene; this protein is overexpressed in prostate cancer, as well as in HGPIN [281]. The gene discussed is FBL; the disease is prostate carcinoma.