RB1 and Familial prostate cancer: In this context, Bova and coworkers have performed a combined analysis of whole genome sequencing and transcriptome sequence analysis of multiple prostate cancer metastases in a single patient: liver metastases displayed the presence of AR pL702H mutation, associated with increased expression of AR-regulated genes; the metastases displayed truncal mutation in PIK3CG, homozygous deletion of TP53, hemizygous deletion of RB1 and CHD1, and amplification of FGFR1 [51].