In fact, Rodriguez-Bravo and coworkers discovered abnormalities of nuclear pores composition during progression to metastatic, lethal prostate cancer, related particularly to the overexpression of the importin Nup POM121; POM121 overexpression promotes nuclear import of key transcription factors driving prostate cancer development, including AR, MYC, and GATA2 [214]. Here, POM121 is linked to Familial prostate cancer.