The dichotomous function of FOXA1 in AR signaling may be explained taking into account the key role of this transcription factor as a pioneer factor in the reprogramming of the AR and GATA2 cistromes: FOXA1 represses AR binding to DNA, while GATA2 cooperates with the AR in androgen-mediated gene expression in prostate cancer [651]. The gene discussed is FOXA1; the disease is prostate carcinoma.