The gene loci most frequently affected by structural variation contained key driver genes of prostate cancer, including androgen receptor, the transmembrane serine protease 2 (TMPRSS2) and ETS transcription factor genes that produce TMPRSS2/ERG fusion protein, the oncogene MYC, FOXA1, and PTEN and clusters of deletions affecting genes located at the level of fragile sites [62]. The gene discussed is TMPRSS2; the disease is Familial prostate cancer.