PTGS2 and hepatocellular carcinoma: Reportedly, the upregulation of Cyclooxygenase-2 (COX-2), an inducible enzyme frequently found in inflammatory tissue, correlates with angiogenesis, invasion, relapse, chemo-resistance, and tumorigenesis in HCC [191], ultimately promoting hepatoma cell growth by inhibiting apoptosis through AKT activation [192,193].